Stem cells are self-complementary undifferentiated cells, according to their tissue location, may be differentiated into specialized cells, such as skin cells or blood cells. Within tissue homeostasis, via cell production (growth) and the elimination of balance (regression) between the implementation. In contrast with the tissue growth, the organization needed to subside cellular and molecular signals, is not clear. To explore the physiological tissue subsided, the research team used mouse hair follicles.
In this study, the research team to use in vivo microscopic imaging, tracking mouse skin in vivo stem cell behavior and found that regression of stage (regression phase) to eliminate most of the epithelial cells by two different mechanisms, these two mechanisms, respectively, is: terminally differentiated basal cells and basal cell apoptosis spatial gradient. In addition, studies have shown that basal epithelial cells act together as phagocytes to remove the epithelial cell death nearby. Cells and by genetic ablation techniques, researchers have shown that the epithelial cell death and is induced by Recombinant human Protein atonal homolog 1 http://www.cusabio.com/Recombinant-Protein/Recombinant-human-Protein-atonal-homolog-1-11031344.html and mesenchymal cell activation crosstalk. It is noted that these data suggest that organizations can take action to reduce subside stem cell pool, because too much can lead to regression of inhibition with regenerative capacity basal epithelial cells.
The researchers observed that stem cell niche (stem cell niche), or the surrounding area, stem cell growth or death have played a key role. At the same time, the researchers were surprised to find that the pool of stem cells stem cells stem cells in other death for food. This discloses a mechanism for removal of dead cells, a process previously observed in mammalian glands, but has never been observed in the skin.
