Recent Entries

• Introduction to Protein Quantification Service

  by chen shanshan Jun 30
  As we all know, dynamic changes of proteome abundance in cells have important effects on various life processes. For example, in the occurrence and development of many diseases, the expression of some proteins is often accompanied by abnormal. Protein Quantification Service is th...

• Rapid Determination Method of Veterinary Drug Residues in Food

  by chen shanshan Jun 29
  Veterinary drug residue testing Types of veterinary drug residues Antibiotics: chloramphenicol, tetracycline, oxytetracycline, penicillin, etc.; Sulfas: Sulfadiazine, Sulfamethazine, etc.; Furans: furazolidone, nitrofurans, nitrofurantoin, etc.; Hormones and β-stimulants: Clenbu...

• Seven FAQs about Human Immune Globulin

  by chen shanshan Jun 28
  What is human immunoglobulin? It is made from the plasma of healthy people, separated and purified to remove anti-complement activity, processed by virus inactivation, and freeze-dried. The human immune globulin is not less than 96% of the total protein. It contains a suitable amount of ...

• CD Genomics Launches NGS Panels for SARS-CoV-2 Detection and Re

  by chen shanshan Jun 27
  CD Genomics has developed a very comprehensive NGS panels for sequencing, coronaviruses detection, phylogenetic analysis and molecular characterization of the 2019 novel coronavirus (namely SARS-CoV-2, and the virus is responsible for COVID-19). The panels are designed to obtain complete viral genom...

• The Bottleneck of RNA Drug Delivery System (III)

  by chen shanshan Jun 25
  Until the end of 2016, the breakthrough of technology and the approval of new products set off a new round of investment cooperation. Bios/Ionis' antisense oligonucleotide Nusinersen for the treatment of spinal muscular atrophy (SMA) was approved by the FDA for marketing and achieved sales of US$8...

• Stem Cells Used in COVID-19

  by chen shanshan Jun 24
  As of June, there were more than 7 million cases of COVID-19 worldwide. Compared with the rising number of infections, what is even more disturbing is that many countries are overwhelmed by medical resources, and there is a lack of special drugs to rescue critical patients. The function of the st...

• The New Technology CAR-T Is Expected to Overcome AIDS After Bei

  by chen shanshan Jun 23
  Abstract: HIV continues to be a major global public health issue, having claimed more than 32 million lives so far. However, the increasing access to effective HIV prevention, diagnosis and treatment has made it less threatening. Recently, convertibleCAR-T cell has been a hot issue for its grea...

• A List of Ten Applications of Flow Cytometry

  by chen shanshan Jun 22
  Flow cytometry (FCM) is a technique used to detect and measure physical and chemical characteristics of a population of cells or particles. During this process, a sample containing cells or particles is suspended in a fluid and injected into the flow cytometer instrument. Flow cytometry ca...

• Hydroponic Gardening - Are LED Grow Lights Best?

  by chen shanshan Jun 9
  If you're about to get started in hydroponic gardening one of the most important choices you can make is the type of grow light you use. You can choose an LED grow light, HID, Metal Halide, fluorescent, sodium lights and more. Many people who have been gardening indoors for years used high-intensi...

• An Experiment to Whole-genome Resequencing Data Analysis (II)

  by chen shanshan May 31
  SV formation mechanism analysis, including the identification and discovery of the following main mechanisms that may exist: (A) Homology-mediated orthologous sequence segment recombination (NAHR); (B) Non-homologous recombination (NHR) related to DNA double-strand break repair or replication fork...

• A New Discovery of Alzheimer’s Disease—TREM2

  by chen shanshan May 30
  Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the Center for Stroke and Dementia Research (ISD) at LMU Medical Center have found that a protein called TREM2 may have a mitigating effect on the course of Alzheimer's disease. In a new study led by Professor Christian Haass...

• Proteolysis-Targeting Chimeras as Tools in Drug Development (II

  by chen shanshan May 28
  3.2. Off-target protein degradation Multiple studies have shown that PROTACs are not entirely selective and can degrade proteins other than the primary target. Degradation of a protein that is not directly bound by the PROTAC can arise as a consequence of “bystander degradation” where t...

• An Overview of the Relationship Between Complement System and A

  by chen shanshan May 27
  3.3 Dermatomyositis Inflammatory myopathy is a group of acquired diseases characterized by inflammatory cell infiltration of skeletal muscle and muscle fiber necrosis, usually manifested as moderate to severe muscle weakness and infection, mainly including polymyositis, dermatomyositis and inclusio...

• An Overview of Application of Protein Cross-linking Agent

  by chen shanshan May 26
  Protein cross-linking agents are a class of small molecule compounds that have 2 or more reactive ends for special groups (-NH2, -COOH, -HS, etc.) and can be coupled to 2 or more molecules, respectively, so that these molecules bind together. In the 1970s, people generally used glutaraldehyde as a p...

• NKTR-214 combined with Nivolumab is also effective for PD-L1 ne

  by chen shanshan May 25
  In recent years, immunological checkpoint inhibitors represented by anti-PD-1 monoclonal antibodies have revolutionized cancer treatment. However, there are still many patients who have no response to immune checkpoint inhibitors, especially those PD-L1 negative patients. Therefore, it is necessary ...

• Creative Biolabs Released Modotuximab for Research Use

  by chen shanshan May 24
  April 22, 2020, Creative Biolabs, as a leading supplier in recombinant antibody discovery and manufacturing, is equipped with cutting-edge hybridoma development and phage display platforms to be able to offer customers with high-quality and professional services. Its product lines are from antibody/...

• Why Choose LED Grow Lights?

  by chen shanshan May 20
  LED Grow Lights have increased in popularity during the last few years and have turned into a safe option to traditional lighting. LED lighting is a good source of artificial light for your plants, and they're Eco friendly too. They may also offer your wallet a rest mainly because LED Grow Lights ar...

• Tactical Equipment For Everyone

  by chen shanshan May 14
  It's hardly surprising that terms such as tactical equipment or tactical gear make people think about things like multicam tactical vests with ammunition pouches worn by soldiers and SWAT team members. But just because something was designed with these users in mind doesn't mean those products are n...

• It's Got to Be the Shoes, Money!

  by chen shanshan May 5
  Actually, it's the lack of shoes. Recently there has been a big barefoot movement in the fitness industry. More and more studies are showing the advantages to walking, running, or any type of training while barefoot. Shoemakers like Nike, New Balance, Merrell, and Reebok have all added a minimalis...

• Ofatumumab Can Prolong PFS in CLL Patients

  by chen shanshan Apr 29
  Ofatumumab is a fully humanized, targeted anti-CD20 monoclonal antibody for refractory chronic lymphocytic leukemia (CLL), which is not effective for fludarabine and alenduzumab. This product can specifically target CD20 cell apoptosis by specifically binding to small ring antigens on small and larg...

• The Ultimate Guide to Whole Genome Resequencing: Basic and Adva

  by chen shanshan Apr 28
  Introduction Whole-genome resequencing is to perform genome sequencing on different individuals of a species with a reference sequence, and use this as a basis to analyze genetic differences at the individual or group level. Through whole-genome resequencing, researchers can find a large number o...

• Introduction to Stem Cell

  by chen shanshan Apr 26
  What Is the Stem Cell?   Figure 1. Stem Cell Stem cells are a kind of cell population with self-renewal, high proliferation and multi-directional differentiation potential, that is, these cells can maintain the size of their own cell population through cell division, and can f...

• Introduction to Bioinformatics

  by chen shanshan Apr 24
  What is Bioinformatics?   Figure1. Bioinformatics analysis Bioinformatics is a discipline studying the collection, processing, storage, dissemination, analysis and interpretation of biological information, and it is also a new discipline formed by the combination of life science and computer...

• Development and Application of Environmental Protection Enzymes

  by chen shanshan Apr 23
  In the face of increasingly severe global environmental pollution problems, the combined development of environmental engineering technology and biotechnology has provided new technical means for environmental pollution control. There are many defects in the traditional pollution control methods. Th...

• What do we know about nuclear magnetic resonance?

  by chen shanshan Apr 21
  Nuclear magnetic resonance is a physical process in which the nuclear moment is not zero, the spin energy level undergoes Zeeman splitting under the action of an external magnetic field, and resonance absorbs radio frequency radiation of a certain frequency. Nuclear magnetic resonance spectro...

• Alemtuzumab is Associated with Increased CNS Inflammation in Pa

  by chen shanshan Apr 19
  Alemtuzumab is a highly effective MS drug that has been approved in more than 60 countries and is used by more than 12,000 patients worldwide. However, the risk of secondary autoimmune diseases is almost 50%, and some of them are life-threatening diseases such as platelet and kidney disease.  ...

• Cultivation of Microalgae

  by chen shanshan Apr 16
  According to the different nutrient modes of microalgae, the culture modes can be divided into photoautotrophic culture, mixed culture and heterotrophic culture.   Photoautotrophic culture Photosynthetic autotrophic growth of microalgae is affected by many environmental factors, including nu...

• Tactical Survival Gear

  by chen shanshan Apr 13
  One aspect of survival that should be considered when facing a disaster is surviving the human element. You might think that you are 100% ready with food, water, shelter, and some survival gear tucked away in your bug out bag. You could also be dead wrong. What are you going to do when someone try's...

• Treat Your Feet Well With Shoes From Five Fingers

  by chen shanshan Apr 3
  The style of Five Fingers Shoes isn't the only thing unusual about them. The glove-inspired design of this unique shoe provides each toe with its own separate compartment, allowing a freedom of movement rarely felt in traditional shoes. This natural movement similar to a barefoot stride will help st...

• Effective Therapeutics Targeting SARS-CoV-2 Are on the Way

  by chen shanshan Mar 30
  The latest outbreak of novel coronavirus pneumonia cases caused by the severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 in Wuhan, China makes the whole world worried. The coronavirus disease 2019 (COVID-19), named by the WHO has led to more than 75000 cases worldwide, with more than 2000 ...

• Scientists explain the role of DNA methylation in biological ac

  by chen shanshan Mar 26
  Methylation is one of the main ways of regulating gene expression. Studying the methylation of chromosomal DNA is the basis for understanding gene regulation. After processing DNA with standard bisulfite methods, unmethylated cytosine C is deaminated to form uracil U. After PCR amplification, uracil...

• New Method for Profiling of DNA Methylation and Chromatin Struc

  by chen shanshan Mar 24
  The DNA methylation status in cells is significantly different in different types of cells, and its dynamic regulation may be closely related to the structure of chromatin in the nucleus. There are already available technologies for sequencing DNA methylation (whole genome bisulf...

• Studies Revealed the Cryo-EM structure of Human Lysosomal Cobal

  by chen shanshan Mar 23
  Recently, Yuxing, Chen and Congzhao, Zhou, professors of National Research Center for Microscale Material Science and Department of Life Science and Medicine of University of Science and Technology of China, collaborated with Linfeng Sun's group to analyze the near-atomic resolution 3D structure of ...

• The Unraveling Structure and Function of Bispecific Antibody (P

  by chen shanshan Mar 21
  SEED is a transformation strategy for mismatches between different heavy chains that has appeared in recent years. This technology is mainly based on the analysis of antibody Fc structure. In the complementary cross regions (AG and GA) of the two chains CH3 domains, the partial structures that repla...

• The points to consider for vaccine development of SARS-CoV-2 (P

  by chen shanshan Mar 19
  Vaccine preparation technology has undergone multiple times of "evolutions". The most common vaccines are the first-generation live attenuated vaccines and inactivated vaccines, which are easy to make and have good immune effects, but the components are complex and there is a risk of rec...

• Gene editing and editing technologies (Part Two)

  by chen shanshan Mar 17
  Based on the work of Chandrasegaran, the Dana Carrol team at the University of Utah School of Medicine's Department of Biochemistry used ZFNs to inject Drosophila embryos for the first time to achieve gene editing in animals. Subsequently, scientists used ZFNs to edit target genes in animal, plant, ...

• Cytotoxin Payloads: Potent Missile Parts of Antibody-drug Conju

  by chen shanshan Mar 16
  Known as one of the novel generations of antibody technology, antibody-drug conjugates (ADC) are composed of antibody, cytotoxic payload and linker, which have both the high specificity of antibody and the high toxicity of cytotoxin to tumor.     How to select an ADC target? It is simila...

• Three Common Cat Litter Box Problems and Solutions

  by chen shanshan Mar 10
  Cats are one of the most convenient pets. Unlike dog owners, cat owners can leave for up to 3 days at a time since most cats are trained to use a litter box. Dog owners must get a sitter or board their dogs in a kennel because 1) they eat all their food the first day and 2) they do their business al...

• The New Reality of Finding Your Correct Combat Boot Size

  by chen shanshan Mar 5
  Many of my customers often ask about purchasing the right size Belleville combat boots for their feet, For that matter, the following answer applies to all makes. The reason this question is so often fielded is that experience has told these people using their regular shoe size never seems to apply ...

• Cat Litter Boxes and Pregnancy

  by chen shanshan Feb 28
  In the duration of pregnancy a woman has many things to ponder and worry about. A few things are not to eat uncooked fish or sushi. Don't eat cold cuts that haven't been heated properly, and one that many may not know is not cleaning cat litter boxes during pregnancy.   While we may not think...

• Can cancer cells be starved to death?

  by chen shanshan Feb 26
  Tumors need to devour enough nutrients to power their uncontrolled growth. For decades, researchers have been trying to develop new drugs that can cut off their “food” supply. A study published on November 8 showed that an upgraded version of a failed anticancer drug can not only prevent...